Question about Pseudomonas Recovery From Purified Water

The Question posed on LinkedIn:

Dear All, please suggest how to proceed when pseudomonos (sic) is detected in purified water ?

My reply was this:

Hi Samshad.

Following a sanitation cycle, I would conduct full screen monitoring of your PW system to determine if the Pseudomonas sp. continues to be recovered.

To consider/investigate:

  • sanitation validation data
  • CFU of Ps. recovered
  • historical CFU (week-month)
  • based on count, would a system flush help?
  • bioload on finished goods made with affected PW
  • filter integrity test if applicable
  • TMAC/objectionable organism results
  • affected product intended use
  • risk of releasing batch & end user impact

Kind regards